Gokul Ramaswami

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

The paper identifies developmentally regulated alternative 3' end cleavage of transcripts in Drosophila spermatogenesis, showing how it affects protein expression during differentiation.

The paper develops a CRISPR-based mutagenesis approach combined with machine learning to model cis-regulatory features of ADAR-mediated RNA editing, explaining over 70% of editing level variation.

The paper identifies gene co-expression modules in human spinal cord RNA-seq data that are dysregulated in ALS, linking them to specific biological processes and cell types involved in disease.

The paper identifies widespread transcriptomic dysregulation across multiple cortical regions in ASD, showing regional variation and genetic enrichment in synaptic and protein folding genes.

This study identifies transcriptomic changes in non-human primate brains exposed to maternal immune activation, revealing alterations in retrotransposition, synaptic connectivity, and myelination.

The paper identifies a convergent molecular subtype in ASD by integrating epigenomic and transcriptomic data, revealing shared dysregulation and links to immune processes and genetic risk variants.

The paper identifies brain-wide and region-specific gene co-expression modules using RNA-seq data and links them to disease risk variants and biological processes.

This study identifies widespread hypo-editing in ASD brains and links RNA editing dysregulation to Fragile X syndrome through FMRP/FXR1P-ADAR interactions.

The paper characterizes genetic control of gene expression and splicing in developing human brains using eQTL and sQTL analysis, identifying novel regulatory regions and links to neuropsychiatric disorders.