HPF1-dependent PARP activation promotes LIG3-XRCC1-mediated backup pathway of Okazaki fragment ligation
Soichiro Kumamoto, Atsuya Nishiyama, Yoshie Chiba, Ryota Miyashita, Chieko Konishi, Yoshiaki Azuma, Makoto Nakanishi
The paper shows that PARP1-HPF1-dependent ADP-ribosylation recruits LIG3-XRCC1 to chromatin to mediate Okazaki fragment joining when LIG1 is absent.
Nucleic Acids Research · Apr 1, 2021Peer-reviewedMolecular Biology