Charles Nelson

Multi-dimensional regulation of LIN-28 temporal expression dynamics in the C. elegans heterochronic gene cascade

This study identifies multiple regulatory inputs governing LIN-28 expression dynamics in C. elegans, showing how microRNAs and a long non-coding RNA collectively repress LIN-28 while positive regions counteract this repression.

C. elegans LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of lin-46 mRNA

This study shows that LIN-28 in C. elegans represses LIN-46 expression via the 5'UTR of lin-46 mRNA, leading to heterochronic defects when LIN-46 is expressed prematurely.

A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA

The paper identifies Caenorhabditis species lacking the let-7 microRNA and shows the heterochronic gene network remains functional without it.

Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity

The paper shows that trans-splicing of the C. elegans let-7 primary transcript produces an RNA that negatively regulates let-7 microRNA biogenesis and let-7 family microRNA activity.