Victor Ambros

Cold Shock Domain Protein LIN-66 cooperates with microRNA-pathway buffering to safeguard developmental timing

The paper shows LIN-66, a cold shock domain protein, works with microRNA pathways to control developmental timing by limiting early fate regulators' persistence.

Multi-dimensional regulation of LIN-28 temporal expression dynamics in the C. elegans heterochronic gene cascade

This study identifies multiple regulatory inputs governing LIN-28 expression dynamics in C. elegans, showing how microRNAs and a long non-coding RNA collectively repress LIN-28 while positive regions counteract this repression.

A comprehensive resource for studying microRNA evolution and microRNA-mediated development and whole-body regeneration in the acoel worm Hofstenia miamia

Modeling neurodevelopmental disorder-associated hAGO1 mutations in C. elegans Argonaute ALG-1

The paper models hAGO1 mutations in C. elegans to study their impact on miRNA function and gene expression, revealing allele-specific disruptions in miRNA profiles and gene regulation.

Critical contribution of 3' non-seed base pairing to the in vivo function of the evolutionarily conserved let-7a microRNA

This study investigates the in vivo role of the 3' non-seed region in let-7a microRNA, showing its importance in target repression and distinguishing let-7a from its paralogs.

C. elegans LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of lin-46 mRNA

This study shows that LIN-28 in C. elegans represses LIN-46 expression via the 5'UTR of lin-46 mRNA, leading to heterochronic defects when LIN-46 is expressed prematurely.

A cohort of Caenorhabditis species lacking the highly conserved let-7 microRNA

The paper identifies Caenorhabditis species lacking the let-7 microRNA and shows the heterochronic gene network remains functional without it.

Environmental pheromone and endocrine signals correct heterochronic developmental phenotypes caused by insufficient expression of let-7 family microRNAs in C. elegans

The paper shows that environmental pheromones and endocrine signals correct developmental defects in C. elegans caused by low let-7 microRNA expression by rewiring gene regulatory networks.

Trans-splicing of the C. elegans let-7 primary transcript developmentally regulates let-7 microRNA biogenesis and let-7 family microRNA activity

The paper shows that trans-splicing of the C. elegans let-7 primary transcript produces an RNA that negatively regulates let-7 microRNA biogenesis and let-7 family microRNA activity.

The C. elegans heterochronic gene lin-28 coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesis

This study shows that lin-28 coordinates hypodermal and somatic gonad development in C. elegans, with hypodermal lin-28 expression sufficient to restore normal gonad morphology in mutants.

Regulation of Nuclear-cytoplasmic Partitioning by the lin-28-lin-46 Pathway Reinforces MicroRNA Repression of HBL-1 to Confer Robust Cell-fate Progression in C. elegans

The paper shows the lin-28-lin-46 pathway regulates HBL-1 nuclear accumulation independently of let-7 microRNAs, contributing to robust cell-fate progression in C. elegans.