Development of Bioisosteric Iboga-alkaloids as Antinociceptive and Anxiolytic Agents with Neuroprotective Effects
Abhishek Gupta, Tuhin Bhattacharya, Subhamoy Pratihar, Sabnur Parvage, Swrajit Nath Sharma, Arnab Sarkar, Akash De, Sanmoy Karmakar, Sanjit Dey, Surajit Sinha
This paper develops bioisosteric iboga analogs with improved antinociceptive and anxiolytic properties and reduced cardiotoxicity compared to natural iboga alkaloids.
bioRxiv · Feb 24, 2025 · PreprintPhysiology