Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats
Julio D. Zuarth Gonzalez, Alexandria K. Ragsdale, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Lance Richard McMahon, Samuel Obeng, Jenny L. Wilkerson
This study examines the respiratory effects of mitragynine and 7-hydroxymitragynine in rats, finding that 7-HMG causes respiratory depression reversed by naloxone, while MG increases breathing independently of opioid receptors.
bioRxiv · May 16, 2025Pharmacology & Toxicology