Pharmacology & ToxicologybioRxiv
Mitragynine and 7-Hydroxymitragynine: Bidirectional Effects on Breathing in Rats
Julio D. Zuarth Gonzalez, Alexandria K. Ragsdale, Sushobhan Mukhopadhyay…·Jenny L. Wilkerson
This study examines the respiratory effects of mitragynine and 7-hydroxymitragynine in rats, finding that 7-HMG causes respiratory depression reversed by naloxone, while MG increases breathing independently of opioid receptors.
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