ImmunologybioRxivPreprint
Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies
Rajagopal Murugan, Anton Hanke, Opeyemi Ernest Oludada…·Hedda Wardemann
This study shows that somatic hypermutation increases cross-reactivity of anti-PfCSP antibodies by enhancing flexibility in antigen-bound complexes, but reduces serum stability.
DOI 10.1101/2024.07.24.604858