Hedda Wardemann

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

The paper develops a 31-parameter spectral flow cytometry panel to analyze immune responses in mouse B and T cells across multiple tissues.

This study identifies conserved CD4+ T cell epitopes in PfCSP and shows their HLA-independent presentation, suggesting potential for strain-transcending malaria vaccines.

This study shows that somatic hypermutation increases cross-reactivity of anti-PfCSP antibodies by enhancing flexibility in antigen-bound complexes, but reduces serum stability.