Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies
Rajagopal Murugan, Anton Hanke, Opeyemi Ernest Oludada, Giulia Costa, Yevel Flores-García, Ghulam Mustafa, Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Moses Dennison, Georgia D. Tomaras, Fidel P. Zavala, Elena A. Levashina, Randal R. Ketchem, Rebecca C. Wade, Hedda Wardemann
This study shows that somatic hypermutation increases cross-reactivity of anti-PfCSP antibodies by enhancing flexibility in antigen-bound complexes, but reduces serum stability.
bioRxiv · Jul 24, 2024 · PreprintImmunology