Author

Anton Hanke

University of GenevaORCID 0000-0001-9552-1201Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Organism:human· 2 Assay:structural biology· 2 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Christina ElsneriD· 2 shared Enrica BordignoniD· 2 shared Francesco Luigi GervasioiD· 2 shared Elena A. LevashinaiD· 1 shared Fidel P. ZavalaiD· 1 shared Georgia D. TomarasiD· 1 shared Ghulam MustafaiD· 1 shared Gillian Q. HorniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Christina ElsnerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

How specific structural differences of Bcl2 proteins modulate the interaction with BH3 domains and apoptotic function

Anton Hanke, Christina Elsner, Simone Aureli, Enrica Bordignon, Francesco Luigi Gervasio

The paper investigates how structural differences in Bcl2 proteins affect BH3 domain interactions and apoptotic function using simulations and experimental validation.

bioRxiv · Jul 17, 2026 · PreprintBiophysics

Structural and dynamic basis of indirect apoptosis inhibition by Bcl-xL: a case study with Bid

Christina Elsner, Anton Hanke, Oscar Vadas, Francesco Luigi Gervasio, Enrica Bordignon

This study provides the structural model of the Bcl-xL/tBid complex at the mitochondrial membrane, revealing its dynamic architecture and mechanism of indirect apoptosis inhibition.

Proceedings of the National Academy of Sciences · May 11, 2026Peer-reviewedBiophysics

Somatic hypermutation-mediated paratope flexibility improves the cross-reactivity of human malaria antibodies

Rajagopal Murugan, Anton Hanke, Opeyemi Ernest Oludada, Giulia Costa, Yevel Flores-García, Ghulam Mustafa, Kan Li, Richard H.C. Huntwork, Gillian Q. Horn, S. Moses Dennison, Georgia D. Tomaras, Fidel P. Zavala, Elena A. Levashina, Randal R. Ketchem, Rebecca C. Wade, Hedda Wardemann

This study shows that somatic hypermutation increases cross-reactivity of anti-PfCSP antibodies by enhancing flexibility in antigen-bound complexes, but reduces serum stability.

bioRxiv · Jul 24, 2024 · PreprintImmunology