Core-N-glycans are atypically abundant at the neuronal surface and regulate glutamate receptor signaling
Chun-Lei Zhang, Cédric Moutoussamy, Matthieu Tuffery, Alexandre Varangot, Rebecca A. Piskorowski, Cyril Hanus
The paper shows core-N-glycans are abundant on neuronal surfaces and impair NMDA receptor-dependent synaptic plasticity by reducing synaptic AMPA receptor expression and slowing AMPA receptor desensitization.
bioRxiv · Mar 25, 2024 · PreprintCell Biology