Chun-Lei Zhang

This paper creates a knockin mouse model with a K198R mutation in CK2 kinase, showing ASD-like behaviors and synaptic deficits, validating it as a model for Okur-Chung Neurodevelopmental Syndrome.

The paper shows core-N-glycans are abundant on neuronal surfaces and impair NMDA receptor-dependent synaptic plasticity by reducing synaptic AMPA receptor expression and slowing AMPA receptor desensitization.

This study investigates the role of hippocampal synaptic plasticity in memory consolidation during ripple activities, finding that it is essential during consolidation but not encoding or recall.

The paper identifies a synaptic novelty signal in hippocampal circuits that drives a switch from generalization to discrimination during memory formation.

The paper investigates how inhibitory neurons shape preparatory signals in the mouse frontal cortex during motor planning, finding distinct roles for parvalbumin and somatostatin interneurons.

This study shows that impaired AMPA receptor surface diffusion contributes to synaptic plasticity and memory deficits in Huntington’s disease, and that tianeptine can restore these functions.