TDP-43 loss of function drives aberrant splicing in Parkinson's disease
Jonathan Brenton, Jordan Follett, Raja Sekhar Nirujogi, Christina E. Toomey, Patricia Lopez-Garcia, James R. Evans, Yeon J. Lee, Khaja Mohieddin Syed, Guillermo Rocamora Perez, Aine Fairbrother-Browne, Karishma D’Sa, Melissa Grant‐Peters, Joanne Lachica, Amy R. Hicks, Aaron Z. Wagen, , Mina Ryten
The paper identifies splicing dysregulation in Parkinson's disease linked to TDP-43 loss of function and shows its association with genetic mutations and cellular models.
bioRxiv · Sep 4, 2025 · PreprintNeuroscience