Jordan Follett

This study investigates the effects of Vps35 p.D620N mutation on microglial function, showing increased LRRK2 kinase activity, chronic inflammation, and altered immune responses in mice.

This study shows that disrupting Lrrk2 function in both directions leads to T cell dysregulation and exhaustion-like immune responses in mice.

This study identifies Rab32 as a mediator linking peripheral inflammation to Lrrk2 kinase activity in microglia, with Tfe3 regulating Rab32 expression and Lrrk2 activation.

The paper identifies splicing dysregulation in Parkinson's disease linked to TDP-43 loss of function and shows its association with genetic mutations and cellular models.

This study shows midbrain dopamine neurons modulate splenic immunity via a brain-to-body circuit involving the DVC and celiac ganglion, reducing spleen weight and naive CD4+ T-cell populations.

This study characterizes Dnajc12 knockout mice, showing reduced dopamine and serotonin levels, altered behavior, and potential therapeutic implications for biogenic amine disorders.

The paper shows that inhibiting LRRK2 kinase activity rescues dopamine deficits in VPS35 p.D620N knock-in mice by normalizing DAT function and reducing hyperlocomotion.

This study identifies genetic modifiers of LRRK2 mutations in Parkinson's disease, finding a significant variant in CORO1C and a polygenic risk score effect on penetrance.

The paper refutes the claim that TMEM230 c.422G>T is a causative mutation for Parkinson disease by showing it is not present in affected family members.