Aaron Z. Wagen

TDP-43 loss of function drives aberrant splicing in Parkinson's disease

The paper identifies splicing dysregulation in Parkinson's disease linked to TDP-43 loss of function and shows its association with genetic mutations and cellular models.

Independent Generation of Amyloid-β via Novel APP Transcripts

The paper identifies novel APP transcripts that generate Aβ independently of β-secretase, showing their expression and presence in CSF.

Astrocytic RNA editing regulates the host immune response to alpha-synuclein

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

Ancestry-specific gene expression in peripheral monocytes mediates risk of neurodegenerative disease

The paper shows ancestry-specific gene expression in monocytes mediates neurodegenerative disease risk through innate immune cell expression of neurodegeneration-related genes.

RNA editing is a molecular clock in unmodified human cells

This paper introduces T2, a method using RNA editing to estimate transcriptional age and identify transient transcriptional programs in human cells.

GLP-1 receptor agonism ameliorates Parkinsons disease through modulation of neuronal insulin signalling and glial suppression

This study shows GLP-1R agonism improves Parkinson's disease by restoring neuronal insulin signaling and reducing glial inflammation, with clinical benefits in patients with higher baseline MAPK expression.

Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases

The paper identifies local genetic correlations between neurodegenerative and neuropsychiatric diseases using LAVA, revealing shared genomic regions and potential therapeutic targets.