Author
The Francis Crick InstituteORCID 0000-0001-6636-5940Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Laura Mahoney‐Sanchez, Hannah J Lucas-Clarke, Alexis Penverne…·Sonia Gandhi
This study shows that the SNCA A53T mutation increases vulnerability to ferroptosis in neurons and microglia, suggesting 15-LO inhibition as a potential therapeutic target for Parkinson's disease.
Jonathan Brenton, Jordan Follett, Raja Sekhar Nirujogi…·Mina Ryten
The paper identifies splicing dysregulation in Parkinson's disease linked to TDP-43 loss of function and shows its association with genetic mutations and cellular models.
James R. Evans, Melissa Grant‐Peters, Joseph S. Beckwith…·Sonia Gandhi
The paper identifies microglial activation and alpha-synuclein oligomers as drivers of early neuroinflammation in Parkinson's disease using transcriptomic and aggregate profiling in early-stage brain samples.
Karishma D’Sa, Minee L. Choi, Aaron Z. Wagen…·Mina Ryten
The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.
Dilan S. Athauda, James R Evans, Laura Mahoney‐Sanchez…·Sonia Gandhi
This study shows GLP-1R agonism improves Parkinson's disease by restoring neuronal insulin signaling and reducing glial inflammation, with clinical benefits in patients with higher baseline MAPK expression.