Adam P. Miller

CaMKII T286 autophosphorylation is not propagated at basal Ca2+ levels and is required only for the induction phase of LTP

This study shows that CaMKII T286 autophosphorylation does not propagate at basal Ca2+ levels and is only required during the early phase of LTP induction.

Mechanism of small heat shock protein client sequestration and induced polydispersity

This study presents cryo-EM structures of sHSPs in apo and client-bound states, revealing mechanisms of client sequestration and polydispersity in sHSP complexes.

Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM.

The paper investigates the structural dynamics of αB-crystallin by mutating the NT-IXI motif, revealing how this affects fibrillar assembly and chaperone function using cryo-EM.

Conserved and divergent features of neuronal CaMKII holoenzyme structure, function, and high-order assembly

This study compares the structure, function, and high-order assembly of neuronal CaMKII and β-isoforms using single-particle EM and biochemical methods, revealing differences in their extended states and clustering behavior.