Actomyosin Contractility is a Potent Suppressor of Mesoderm Induction by Human Pluripotent Stem Cells
Loïc Fort, Vaishna Vamadevan, Wenjun Wang, Ian G. Macara
This study shows that increasing actomyosin contractility blocks mesoderm induction by WNT signaling in hPSCs, while reducing contractility accelerates differentiation.
The Journal of Cell Biology · Feb 25, 2026Peer-reviewedCell Biology