Ian G. Macara

This study shows that increasing actomyosin contractility blocks mesoderm induction by WNT signaling in hPSCs, while reducing contractility accelerates differentiation.

This study shows that non-canonical EGFR signaling, independent of ERK and AKT, is required for Ras-induced apical extrusion of epithelial cells through E-cadherin internalization.

The paper introduces NSC-seq, a CRISPR-based molecular clock to track temporal and clonal events in development and precancer, revealing polyancestral initiation in colonic precancers.

This paper introduces NSC-seq, a direct sgRNA capture method for single-cell CRISPR screens using standard knockout libraries, and characterizes sgRNA expression in three whole-genome libraries.

The paper identifies a self-limiting circuit in mammary cap cells regulated by TGF-beta signaling that prevents conversion to luminal lineage.