Y chromosome shredding in Anopheles gambiae: insight into the cellular dynamics of a novel synthetic sex ratio distorter.
Matteo Vitale, Nace Kranjc, Jessica Leigh, Kyrous Kyrou, Thomas Courty, Louise Marston, Silvia Grilli, Andrea Crisanti, Federica Bernardini
This study uses CRISPR/Cas9 to target the Y chromosome in Anopheles gambiae, causing meiotic defects and a female-biased progeny, providing insights into synthetic sex ratio distortion mechanisms.
bioRxiv · May 9, 2024 · PreprintMolecular Biology