Louise Marston

This study generates CRISPR-edited Anopheles gambiae lines to investigate vgsc's role in insecticide resistance and genetic control, finding haplosufficiency and reduced susceptibility to pyrethroids.

This study investigates the role of the femaleless gene in Anopheles gambiae gametogenesis and its impact on CRISPR-Cas9 gene drive efficacy, showing that disrupting fle causes female sterility and limits gene drive spread.

The paper presents a pipeline to discover and engineer gene drives that overcome resistance in malaria mosquitoes, showing that new resistant alleles can emerge and designing drives that target multiple sites to suppress populations.

This study uses CRISPR/Cas9 to target the Y chromosome in Anopheles gambiae, causing meiotic defects and a female-biased progeny, providing insights into synthetic sex ratio distortion mechanisms.