Aladdin H. Shadyab

This study links clonal hematopoiesis to accelerated frailty and functional decline across multiple organ systems in humans.

This paper conducts a trans-ancestry GWAS of hot flashes, identifies TACR3 as a key genetic target, and finds genetic overlaps with psychiatric disorders.

The paper develops 11 system-specific methylation clocks from blood samples to quantify aging heterogeneity across physiological systems and identifies aging subtypes with distinct disease patterns.

This study shows that changes in transposable element methylation during aging predict age and that demethylation of young L1s is linked to cancer.

The paper identifies a gene-diet interaction modifying the association between macronutrient intake and glycemic traits, highlighting challenges in detecting such interactions due to measurement error and sample size.

This study assesses the broad clinical manifestations of polygenic risk for coronary artery disease using genome-wide PRS in the Women's Health Initiative, finding associations with various biomarkers, outcomes, and unexpected cancer risks.

This study identifies CpG sites associated with BMI and shows that epigenetic BMI prediction correlates with metabolic health markers.

The paper identifies rare non-coding variants from whole genome sequencing in the TOPMed program, showing they contribute significantly to type 2 diabetes heritability.

This study compares methods for constructing genetic risk scores in Hispanics/Latinos using European ancestry GWAS results and finds that using Hispanic/Latino GWASs for SNP weights improves performance.