Author
University of RochesterORCID 0000-0003-1040-8539Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
John C. Martinez, Francesco Morandini, Cheyenne Rechsteiner…·Vera A. Gorbunova
This study shows that cGAS deficiency in mice leads to premature aging through inflammation and de-repression of LINE1 elements.
Lei Justan Zhang, Osama Elsallabi, Carolina Soto-Palma…·Paul D. Robbins
This study identifies fucoidans as senotherapeutics that enhance SIRT6-dependent DNA repair and reduce senescence in aged mice.
Seyed Ali Biashad, Eric C. Hillpot, Francesco Morandini…·Vera A. Gorbunova
This study shows that fucoidan, a seaweed-derived polysaccharide, extends healthspan and lifespan in aged mice by activating SIRT6, which reduces LINE1 retrotransposon activity and epigenetic aging.
Francesco Morandini, Jinlong Y. Lu, Cheyenne Rechsteiner…·Vera A. Gorbunova
This study shows that changes in transposable element methylation during aging predict age and that demethylation of young L1s is linked to cancer.
Francesco Morandini, Cheyenne Rechsteiner, Kevin Pérez…·Alejandro Ocampo
This paper develops an aging clock using chromatin accessibility data from PBMCs and shows it correlates with transcriptional changes during aging.