Tamar Sofer

The paper identifies 16 genetic loci interacting with sleep duration to influence glycemic traits in over 480,000 individuals, revealing distinct biological mechanisms for short and long sleep.

The paper introduces the Proteomic Sex Index (PSI), a continuous measure of plasma proteome alignment with chromosomal sex, showing its association with health and disease traits.

ScreenDMT identifies metabolites consistently linked to sleep disorders across three human cohorts, revealing replicable associations with insomnia, sleep duration, and daytime sleepiness.

This study evaluates polygenic risk scores (PRS) for LDL cholesterol in a diverse Hispanic/Latino population, finding that some PRS improve prediction across subgroups but statin effectiveness varies with genetic ancestry.

The paper examines the relationship between self-reported race, genetic ancestry, and hypertension prevalence among Hispanics/Latinos using the HCHS/SOL dataset.

The paper evaluates polygenic risk scores for dementia prediction in diverse populations, finding that a model with fewer SNPs outperforms one with more SNPs in multiple ethnic groups.

This study evaluates the impact of weak instrumental variables in two-sample Mendelian randomization, showing they can weaken effect estimates in small samples but are less harmful in large ones.

The paper introduces the expected polygenic risk score (ePRS) framework to address population stratification in polygenic risk score analysis by modeling ancestral makeup, showing it provides equitable risk quantification across diverse populations.

This paper improves polygenic prediction of height in an admixed Latino cohort by incorporating genetic ancestry, achieving a 0.1 increase in R² compared to using polygenic scores alone.

This study investigates the association between mosaic loss of Y chromosome (mLOY) and lung function, emphysema, and epigenetic aging in men across multiple cohorts.

This study identifies metabolites linked to insomnia symptoms and develops risk scores predicting cognitive decline in Hispanic/Latino adults.

This study identifies 14 genome-wide significant loci for obstructive sleep apnea, including three independent of BMI, and highlights genetic pathways involving obesity, neurological, and craniofacial factors.

The paper uses 3D craniofacial data and genome-wide association analysis to link craniofacial variation to genetic diversity, evolutionary processes, and clinical conditions in modern humans.

The paper investigates unexplained admixture mapping signals in the Hispanic Community Health Study/Study of Latinos by examining rare variants and expanded common variant regions, finding that common variants explain most signals.

This study examines how non-pathogenic CAG repeats in HTT, ATXN3, and CACNA1A genes affect sleep outcomes, finding sex- and depression-specific associations.

This study examines the longitudinal relationship between epigenetic aging and cognitive aging in Hispanic/Latino adults, finding that increased age acceleration is linked to lower cognitive function and higher risk of MCI.

This paper develops a semi-empirical Bayesian framework to calibrate weak instrumental bias in sex-specific Mendelian randomization studies, revealing significant sex differences in causal effects of sleep phenotypes on cardiovascular diseases.

This study compares old and new local ancestry inference methods in Hispanic/Latino populations using HCHS/SOL data, finding high similarity but some regional discrepancies.

This paper conducts a multi-ancestry GWAS of sleep duration, identifying 234 genome-wide significant loci and showing distinct genetic architecture from other sleep and psychiatric traits.

This study performs genome-wide association analysis on composite sleep health scores, identifying 28 novel loci and confirming 341 previously reported loci, with insights into genetic mechanisms and pathways.

This study conducts a GWAS on fatty acids and oxylipins in HCHS/SOL participants, identifying 19 genetic loci and shared/distinct genetic architecture.

This study identifies gene-environment interactions between excessive daytime sleepiness and genetic variants linked to obstructive sleep apnea severity, revealing novel therapeutic targets.

This study evaluates polygenic risk scores for coronary heart disease in Hispanic/Latino subgroups, finding better performance in Mainland compared to Caribbean subgroups.

This study identifies 17 genetic loci associated with sleep duration and lipid levels, offering potential druggable targets for dyslipidemia in individuals with sleep disturbances.

The paper introduces a parametric bootstrap method to compute confidence intervals for genetic correlations, applied to protein-protein networks from proteomics data.

This study identifies 1,289 genetic signals for type 2 diabetes in 2.5 million individuals, revealing distinct clusters linked to vascular complications and highlighting ancestry-specific genetic risk factors.

The paper identifies common genetic variants for sleep duration across multiple ancestries and finds shared genetic effects in diverse populations.

This study performs a multi-ancestry GWAS on lung function and COPD, identifying 559 genes and 29 pathways, and showing genetic risk scores are associated with COPD across ancestries.

This paper uses pleiotropy to discover new genetic loci for OSA and provide biological hypotheses by combining colocalization tests with pleiotropy analysis.

This study conducts a GWAS of obstructive sleep apnea in the Million Veteran Program, identifying sex-specific genetic loci and highlighting genetic heterogeneity by sex.