Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems
Raghav Sehgal, Yaroslav Markov, Chenxi Qin, Margarita V. Meer, Courtney Hadley, Aladdin H. Shadyab, Ramon Casanova, JoAnn E. Manson, Parveen Bhatti, Ann Zenobia Moore, Eileen M. Crimmins, Sara Hägg, Themistocles L. Assimes, Eric A. Whitsel, Albert Higgins‐Chen, Morgan E. Levine
The paper develops 11 system-specific methylation clocks from blood samples to quantify aging heterogeneity across physiological systems and identifies aging subtypes with distinct disease patterns.
Nature Aging · Sep 15, 2025Peer-reviewedSystems Biology