Michael Mackinley

This study examines white matter changes in schizophrenia patients over two to three years post-onset and finds no longitudinal differences but links white matter alterations to negative symptoms.

This paper uses GPT-3 to quantify global vs. local context sensitivity in speech from schizophrenia patients and finds disorganized speech shows insensitivity to global context, predicting positive thought disorder.

The paper investigates white matter and cortical network changes in early psychosis and finds minimal disruption in first-episode psychosis compared to chronic patients and controls.

The paper examines myelin and microstructural changes in basal forebrain cholinergic nuclei in first-episode psychosis using neuroimaging and transcriptomic data, finding disrupted correlations and clinical correlates.

This study links higher brain glutathione levels to faster treatment response in first episode psychosis patients using 7-Tesla MRS.

The paper uses dynamic causal modeling on resting-state fMRI to examine how left prefrontal stimulation affects positive symptoms of schizophrenia, finding delusions are linked to fronto-striatal circuitry.

The paper investigates glutamate levels and effective connectivity in the salience network of schizophrenia patients using multimodal imaging and cognitive tasks, finding links between glutamate and connectivity deficits.

The paper examines cortical sulcation differences between schizophrenia patients and controls to determine the timing of prenatal insults, finding that schizophrenia-related disruptions predate cognitive deficits.

The paper uses neuroimaging and gene expression data to show that hippocampal volume reductions in first-episode psychosis correlate with serotonin receptor densities and glutamate receptor gene expression.