Matías Preza

A new semi-automated, motility-based screening assay for discovery of compounds with activity against the juvenile stage of Fasciola hepatica

This paper introduces a semi-automated motility-based assay to screen compounds against Fasciola hepatica juveniles, identifying three new compounds with nanomolar activity.

Comparative proteomics reveals a conserved core of tegumental proteins in parasitic flatworms.

This study identifies a conserved core of tegumental proteins in three cestode species through comparative proteomics, revealing shared proteins with trematodes and functional specialization within the tegument.

Coordinated development of the male and female reproductive systems in the cestode Hymenolepis microstoma

The paper characterizes reproductive development in Hymenolepis microstoma, showing coordinated male and female gametogenesis and insemination in vitro.

Repurposing Niclosamide Ethanolamine for Alveolar Echinococcosis Reveals a Disconnect Between In Vitro Efficacy and In Vivo Outcome

This study tests niclosamide ethanolamine (NEN) as a treatment for alveolar echinococcosis, finding strong in vitro efficacy but no significant in vivo effect in mice.

Investigation of the threonine metabolism of Echinococcus multilocularis: the threonine dehydrogenase as a potential drug target in alveolar echinococcosis

This paper investigates threonine metabolism in Echinococcus multilocularis metacestodes, identifies threonine dehydrogenase (TDH) as a drug target, and shows that sanguinarine inhibits TDH and parasite growth.

Stem cell proliferation and differentiation during larval metamorphosis of the model tapeworm Hymenolepis microstoma

This study examines stem cell proliferation and differentiation during larval metamorphosis in Hymenolepis microstoma, identifying rapid tissue formation and lineage-specific gene expression.