Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers
Roser Sanchez-Todo, Borja Mercadal, Edmundo Lopez-Sola…·Giulio Ruffini
This paper develops a laminar neural mass model to simulate Alzheimer's disease progression, showing that PV interneuron dysfunction drives early hyperexcitability and later hypoactivity through electrophysiological biomarkers.