Thermodynamic Analysis of Protein-Nanoparticle Interactions Links Binding Affinity and Structural Stability
Chathuri S. Kariyawasam, Radha P. Somarathne, Naomi C. Hellard, Tanveer Shaikh, Nicholas C. Fitzkee
The paper investigates how protein charge distribution affects adsorption to polystyrene nanoparticles using lysine-to-alanine variants and finds that removing lysine at position 19 enhances binding and stability.
The Journal of Physical Chemistry B · Jan 21, 2026Peer-reviewedBiophysics