Author

Brianna M. Lax

Novo Nordisk FoundationORCID 0000-0002-9727-7529Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein sequence· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Ditte Hededam WelneriD· 3 shared Catarina Mendonça· 2 shared David Harding-LarseniD· 2 shared Felipe Mejia-OtalvaroiD· 2 shared Martina Escorial GarcíaiD· 2 shared Stanislav MazurenkoiD· 2 shared Aboubakar Sako· 1 shared Agata MateraiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioinformatics

Ditte Hededam WelnerORCID

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3 papers

Recent·Most cited

PRIZM: Combining Low-N Data and Zero-shot Models to Design Enhanced Protein Variants

David Harding-Larsen, Brianna M. Lax, Martina Escorial García, Catarina Mendonça, Felipe Mejia-Otalvaro, Ditte Hededam Welner, Stanislav Mazurenko

PRIZM uses low-N data and zero-shot models to rank protein variants, improving design efficiency with minimal experimental data.

Bioinformatics Advances · Oct 5, 2026Peer-reviewedBioinformatics

Data-efficient distal engineering of fluorinase using zero-shot models

David Harding-Larsen, Brianna M. Lax, Christopher K. Weingarten, Aboubakar Sako, Stanislav Mazurenko, Ditte Hededam Welner

This study uses zero-shot models to predict activity-enhancing mutations in fluorinase, leading to improved catalytic efficiency and stability in engineered variants.

Chem & Bio Engineering · Aug 5, 2026Peer-reviewedBioengineering

Efficient and low-impact enzymatic glycosylation with robust sucrose synthase variants

Felipe Mejia-Otalvaro, David John Eliezar P. Delima, Mandy Hobusch, Brianna M. Lax, Catarina Mendonça, Gonzalo N. Bidart, Agata Matera, Alice Branger, Martina Escorial García, Carme Rovira, Ditte Hededam Welner

The paper reports engineered sucrose synthase variants with enhanced activity and stability for efficient glycosylation, achieving high conversion yields and reduced environmental impact.

bioRxiv · Jul 26, 2026 · PreprintBiochemistry