Carme Rovira

This study reveals a covalent mechanism in a bifunctional glycosyltransferase for hexosyl transfer and reports a novel self-priming function for polymerization.

The paper reports engineered sucrose synthase variants with enhanced activity and stability for efficient glycosylation, achieving high conversion yields and reduced environmental impact.

The paper develops a bioorthogonal reporter for MGAT1 by iteratively engineering a UDP-GlcNAc analog with a chemical tag, enabling specific substrate incorporation in mammalian cells.

This study investigates how carbohydrate-active enzymes induce conformational changes in glycans through ring distortions, revealing mechanisms that influence enzyme specificity and inhibitor design.

This paper characterizes the alginate lyase BoPL38 from Bacteroides ovatus, revealing its dual catalytic activities and structural mechanisms for alginate degradation and epimerization.

This study elucidates the molecular mechanism of polysaccharide lyases involved in alginate degradation using structural and computational methods.

This study introduces Glyght, a light-controlled GlyR ligand that selectively modulates glycinergic neurotransmission in vivo, offering new tools for studying inhibitory circuits and phototherapies.