Author

Denis S. Smirnov

Brigham and Women's HospitalORCID 0000-0002-9768-313XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:differential expression· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

August Yue HuangiD· 1 shared Bowen JiniD· 1 shared Bradley T. HymaniD· 1 shared Dennis J. SelkoeiD· 1 shared Derek H. OakleyiD· 1 shared Elizabeth L. Hennessey· 1 shared Guanlan DongiD· 1 shared Katherine Sun-Mi BrowniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenomics

August Yue HuangORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Neurons accumulate disease-specific somatic genomic changes across taupathologic states in Alzheimer's disease

Bowen Jin, Katherine Sun-Mi Brown, Denis S. Smirnov, Samuel M. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey, Guanlan Dong, Shulin Mao, Samadhi P. Wijethunga, Theresa R. Connors, Dennis J. Selkoe, Matthew P. Frosch, Derek H. Oakley, Bradley T. Hyman, August Yue Huang, Michael B. Miller

The paper examines somatic mutations in neurons across tau pathologic states in Alzheimer's disease and finds increased mutation burden and specific mutational signatures in AD neurons.

bioRxiv · May 26, 2025 · PreprintGenomics