Author

Theresa R. Connors

Harvard UniversityORCID 0000-0002-9706-8217Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:dimensionality reduction· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Bradley T. HymaniD· 5 shared Derek H. OakleyiD· 5 shared Matthew P. FroschiD· 3 shared Alexandra N. MelloniiD· 2 shared Lee MakowskiiD· 2 shared Adrià CasamitjanaiD· 1 shared Adrian Vasile DalcaiD· 1 shared Aleksandra A. PetelskiiD· 1 shared

Activity by Year

2023-2025 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersNeuroscience

Bradley T. HymanORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation

Noé Quittot, Dhanush Sivasankaran, Dorothea Böken, Yu Chen, Joshua E Chun, Anne E. Wiedmer, Victoria Derosla, M Martins, Forest A Brooks, Georg Meisl, Matthew W. Cotton, Durga G Arumuganainar, Theresa R. Connors, Alexandra N. Melloni, Matthew P. Frosch, , Bradley T. Hyman

The paper identifies rare bioactive tau oligomers in Alzheimer's brain that can induce templated misfolding and fibril formation, distinguishing them from non-bioactive oligomers.

bioRxiv · Sep 24, 2025 · PreprintNeuroscience

Molecular Polymorphism of tau aggregates in Pick's disease

Jiliang Liu, Theresa R. Connors, Derek H. Oakley, Bradley T. Hyman, Manfred C. Burghammer, Marine Cotte, Lee Makowski

This paper uses micro-XRD and XRF to analyze tau aggregates in Pick's disease, finding distinct elemental compositions and fibril structures in different lesion types.

Neurobiology of Disease · Sep 15, 2025Peer-reviewedNeuroscience

Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance

Mahlon A. Collins, Corinna Friedrich, Megan Elcheikhali, Peyton Stewart, Jason Derks, Theresa R. Connors, Kirstin Altig, Alexandra N. Melloni, Aleksandra A. Petelski, Derek H. Oakley, Bradley T. Hyman, Nikolai Slavov

This study identifies proteomic changes in Alzheimer's disease, revealing decreased 20S proteasome levels and altered ubiquitin system enzymes contributing to protein accumulation.

bioRxiv · May 29, 2025 · PreprintNeuroscience

Neurons accumulate disease-specific somatic genomic changes across taupathologic states in Alzheimer's disease

Bowen Jin, Katherine Sun-Mi Brown, Denis S. Smirnov, Samuel M. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey, Guanlan Dong, Shulin Mao, Samadhi P. Wijethunga, Theresa R. Connors, Dennis J. Selkoe, Matthew P. Frosch, Derek H. Oakley, Bradley T. Hyman, August Yue Huang, Michael B. Miller

The paper examines somatic mutations in neurons across tau pathologic states in Alzheimer's disease and finds increased mutation burden and specific mutational signatures in AD neurons.

bioRxiv · May 26, 2025 · PreprintGenomics

Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

Harshvardhan Gazula, Henry F. J. Tregidgo, Benjamin Billot, Yaël Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adrià Casamitjana, Erica J. Melief, Caitlin S. Latimer, Mitchell D. Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, , Juan Eugenio Iglesias

The paper develops open-source tools for 3D analysis of brain dissection photographs and surface scans, achieving accurate reconstructions and segmentations comparable to MRI.

eLife · Dec 12, 2023Peer-reviewedNeuroscience