Author

Samadhi P. Wijethunga

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Michael B. MilleriD· 3 shared August Yue HuangiD· 2 shared Dennis J. SelkoeiD· 2 shared Elizabeth L. Hennessey· 2 shared Guanlan DongiD· 2 shared Katherine Sun-Mi BrowniD· 2 shared Samantha L. KirkhamiD· 2 shared Samuel M. NaikiD· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenomics

Michael B. MillerORCID

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3 papers

Recent·Most cited

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Guanlan Dong, Chanthia C. Ma, Shulin Mao, Katherine Sun-Mi Brown, Samuel M. Naik, Gannon A. McDonough, Samadhi P. Wijethunga, Junho Kim, Samantha L. Kirkham, Diane D. Shao, Jonathan D. Cherry, Madeline Uretsky, Elizabeth Spurlock, Ann Carolyn McKee, August Yue Huang, , Christopher A. Walsh

The paper identifies somatic genomic alterations in neurons from CTE patients, finding patterns similar to Alzheimer's disease and suggesting mechanisms beyond repetitive head impacts.

Science · Oct 30, 2025Peer-reviewedGenomics

CNS-Tau Specific Antibodies Illuminate Disease Signatures Across Tauopathies

Lei Liu, Yin Zheng, Luke Slominski, Qimin Quan, Adriana Saba, Jean‐Pierre Bellier, Han-Bin Yoo, Andrea Roman, Elizabeth L. Hennessey, Samadhi P. Wijethunga, Elif Lara Okyay, Michael B. Miller, Hyun‐Sik Yang, Dennis J. Selkoe, Jasmeer P. Chhatwal

The paper develops and validates CNS-tau-specific monoclonal antibodies for use in neuropathology and plasma biomarker assays across Alzheimer's disease and primary tauopathies.

bioRxiv · Sep 14, 2025 · PreprintNeuroscience

Neurons accumulate disease-specific somatic genomic changes across taupathologic states in Alzheimer's disease

Bowen Jin, Katherine Sun-Mi Brown, Denis S. Smirnov, Samuel M. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey, Guanlan Dong, Shulin Mao, Samadhi P. Wijethunga, Theresa R. Connors, Dennis J. Selkoe, Matthew P. Frosch, Derek H. Oakley, Bradley T. Hyman, August Yue Huang, Michael B. Miller

The paper examines somatic mutations in neurons across tau pathologic states in Alzheimer's disease and finds increased mutation burden and specific mutational signatures in AD neurons.

bioRxiv · May 26, 2025 · PreprintGenomics