Author

Samuel M. Naik

Brigham and Women's HospitalORCID 0000-0002-0505-4839Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:scRNA-seq· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

August Yue HuangiD· 2 shared Guanlan DongiD· 2 shared Katherine Sun-Mi BrowniD· 2 shared Michael B. MilleriD· 2 shared Samadhi P. Wijethunga· 2 shared Samantha L. KirkhamiD· 2 shared Shulin MaoiD· 2 shared Ann Carolyn McKeeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersGenomics

August Yue HuangORCID

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2 papers

Recent·Most cited

Diverse somatic genomic alterations in single neurons in chronic traumatic encephalopathy

Guanlan Dong, Chanthia C. Ma, Shulin Mao, Katherine Sun-Mi Brown, Samuel M. Naik, Gannon A. McDonough, Samadhi P. Wijethunga, Junho Kim, Samantha L. Kirkham, Diane D. Shao, Jonathan D. Cherry, Madeline Uretsky, Elizabeth Spurlock, Ann Carolyn McKee, August Yue Huang, , Christopher A. Walsh

The paper identifies somatic genomic alterations in neurons from CTE patients, finding patterns similar to Alzheimer's disease and suggesting mechanisms beyond repetitive head impacts.

Science · Oct 30, 2025Peer-reviewedGenomics

Neurons accumulate disease-specific somatic genomic changes across taupathologic states in Alzheimer's disease

Bowen Jin, Katherine Sun-Mi Brown, Denis S. Smirnov, Samuel M. Naik, Samantha L. Kirkham, Elizabeth L. Hennessey, Guanlan Dong, Shulin Mao, Samadhi P. Wijethunga, Theresa R. Connors, Dennis J. Selkoe, Matthew P. Frosch, Derek H. Oakley, Bradley T. Hyman, August Yue Huang, Michael B. Miller

The paper examines somatic mutations in neurons across tau pathologic states in Alzheimer's disease and finds increased mutation burden and specific mutational signatures in AD neurons.

bioRxiv · May 26, 2025 · PreprintGenomics