Inhibiting cough by silencing large pore-expressing airway sensory neurons with a charged sodium channel blocker
Ivan Tochitsky, Sooyeon Jo, Nick Andrews, Masakazu Kotoda, Benjamin Doyle, Jaehoon Shim, Sébastien Talbot, David P. Roberson, Jinbo Lee, Louise Haste, Stephen M. Jordan, Bruce David Levy, Bruce P. Bean, Clifford J. Woolf
This paper develops a novel cationic compound, BW-031, that effectively inhibits cough by targeting large pore-expressing airway sensory neurons through aerosolized delivery.
bioRxiv · Dec 7, 2020 · PreprintNeuroscience