ImmunologybioRxivPreprint
IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity against neuroblastoma
Gabriel A. Barragán, Daniela Cerda, Elisa Landoni…·Leonid S. Metelitsa
This study shows that IL-18 enhances antitumor activity of CAR-NKT cells against neuroblastoma by promoting metabolic reprogramming and reducing exhaustion markers.
DOI 10.1101/2025.04.18.649551