IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity against neuroblastoma
Gabriel A. Barragán, Daniela Cerda, Elisa Landoni, Kshiti H. Dholakia, Piotr Humeniuk, Leidy D. Caraballo Galva, Ying Wang, Gengwen Tian, Boning Yang, Linjie Guo, Michael S. Wood, Xavier Rios, Xin Xu, Amy N. Courtney, Erica J. Di Pierro, , Leonid S. Metelitsa
This study shows that IL-18 enhances antitumor activity of CAR-NKT cells against neuroblastoma by promoting metabolic reprogramming and reducing exhaustion markers.
bioRxiv · Apr 18, 2025 · PreprintImmunology