ImmunologyFrontiers in ImmunologyPeer-reviewed
Human Interleukin-4-Dependent Facilitation of Human IgG Production in PBL-NOG-hIL-4-Tg mice
Yoshie Kametani, Shino Ohshima, Ryoji Ito…·Takashi Shiina
This study shows that NOG-hIL-4-Tg mice support human IgG production through IL-4-dependent B cell maintenance and class switching, with varying subclass responses and tertiary lymphoid structures.
2 citations