Pehr Sommar

Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair

CircMT-RNR2 promotes fibroblast function and maintains mitochondrial redox balance via stabilization of PRDX3, offering a therapeutic target for diabetic foot ulcers.

Spatiotemporal Single-Cell Roadmap of Human Skin Wound Healing

This study maps the spatiotemporal cellular dynamics of human skin wound healing using single-cell and spatial transcriptomics, identifying FOSL1 as critical for re-epithelialization and highlighting differences in chronic wounds.

Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing

The paper identifies circASH1L(4,5) as a protector of miR-129-5p from degradation, enhancing its stability and function in human skin wound healing.

Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport

The paper identifies HOXC13-AS, a lncRNA that regulates epidermal differentiation by interfering with Golgi-ER transport during wound healing.

The injury-induced circular RNA circGLIS3 activates dermal fibroblasts to promote wound healing

The paper identifies circGLIS3 as a circular RNA that promotes wound healing by activating fibroblasts and enhancing extracellular matrix production.

Integrative small and long RNA-omics analysis of human healing and non-healing wounds discovers cooperating microRNAs as therapeutic targets

The paper identifies 17 microRNAs involved in chronic wound healing through integrative RNA-omics analysis and suggests they as therapeutic targets.

Single-cell analysis reveals MHCII expressing keratinocytes in pressure ulcers with worse healing outcomes

The paper uses single-cell transcriptomics to identify MHCII-expressing keratinocytes in pressure ulcers linked to poor healing outcomes.