Xingqi Chen

Identification of an epigenetically and phenotypically distinct peritumoral glioblastoma cell population linked to inferior patient outcome

The paper identifies a distinct peritumoral glioblastoma cell population with unique epigenetic and phenotypic features associated with poor patient outcomes.

RNA polymerase II pausing contributes to maintain chromatin organization in erythrocytes

The paper shows that RNA polymerase II pausing maintains chromatin organization in chicken erythrocytes by repositioning euchromatin and preserving paused promoters.

Profiling chromatin accessibility in formalin-fixed paraffin-embedded samples

This paper introduces FFPE-ATAC, a method for profiling chromatin accessibility in formalin-fixed paraffin-embedded tissues, demonstrating its effectiveness with colorectal cancer samples.

Extrachromosomal DNA is associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

The paper investigates extrachromosomal DNA (ecDNA) in gastric cardia adenocarcinoma, finding associations with chromothripsis, DNA damage, and prognosis based on oncogene amplicons.

Single-cell analysis reveals MHCII expressing keratinocytes in pressure ulcers with worse healing outcomes

The paper uses single-cell transcriptomics to identify MHCII-expressing keratinocytes in pressure ulcers linked to poor healing outcomes.

Conserved cell-lineage controlled epigenetic regulation in human and mouse glioblastoma stem cells determines functionally distinct subgroups

The paper identifies functionally distinct subgroups of glioblastoma stem cells (GSCs) by analyzing cross-species chromatin accessibility, showing that epigenetic regulation is controlled by developmental origin.

A primed immune transcriptional program is activated in oligodendroglia in multiple sclerosis

This study identifies a primed chromatin state in oligodendroglia that facilitates rapid activation of immune gene programs in multiple sclerosis.

Super-resolution Imaging Reveals 3D Structure and Organizing Mechanism of Accessible Chromatin

This study uses super-resolution imaging to reveal the 3D structure and organizing mechanism of accessible chromatin domains.

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

The paper introduces Pi-ATAC, a method combining single-cell chromatin and proteomic profiling, revealing hypoxia's role in shaping the regulome in tumor cells.