Author

Matthew W. Hagen

Fred Hutch Cancer CenterORCID 0000-0002-9812-2262Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Christina Marie TerminiiD· 3 shared Brandon HadlandiD· 2 shared Carli NewmaniD· 2 shared Kelsey A. WoodruffiD· 2 shared Nicollette J. SetiawaniD· 2 shared Rachel WellingtoniD· 2 shared Taylor M. BillingsiD· 2 shared Anita M. QuintanaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCell Biology

Christina Marie TerminiORCID

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3 papers

Recent·Most cited

Cell BiologyBlood AdvancesPeer-reviewedFeb 11, 2026

The bone marrow niche and hematopoietic system are distinctly remodeled by CD45-targeted astatine-211 radioimmunotherapy

Matthew W. Hagen, Nicollette J. Setiawan, Shannon L. Dexter…·Christina Marie Termini

This study shows CD45-targeted astatine-211 radioimmunotherapy more severely impairs hematopoietic recovery and reprograms bone marrow endothelial cells compared to non-targeted radiation.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintNov 7, 2025

Depletion of microenvironmental syndecan-2 impairs hematopoietic stem cell self-renewal and cytokine responses

Matthew W. Hagen, Nicollette J. Setiawan, Rachel Wellington…·Christina Marie Termini

This study shows that syndecan-2 in mesenchymal stromal cells, but not endothelial cells, supports HSC self-renewal and cytokine responses by modulating growth factor signaling.

DOI 10.1101/2025.11.07.687077

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintOct 30, 2025

Inhibition of farnesyltransferase activity diminishes hematopoietic stem cell ex vivo expansion ability

Carli Newman, Isabella M. Alves, Matthew W. Hagen…·Christina Marie Termini

This study shows that inhibiting farnesyltransferase reduces the ex vivo expansion of human and mouse hematopoietic stem cells.

DOI 10.1101/2025.10.30.685582

humanmouse

𝕏 PostBluesky