Rachel Wellington

Single-Cell Behavioromics Enables Fate Prediction of Individual Hematopoietic Stem Cells

This study uses behavioromic analysis to predict hematopoietic stem cell fate with high accuracy and identifies Activin signaling's role in cell behavior and fate.

Depletion of microenvironmental syndecan-2 impairs hematopoietic stem cell self-renewal and cytokine responses

This study shows that syndecan-2 in mesenchymal stromal cells, but not endothelial cells, supports HSC self-renewal and cytokine responses by modulating growth factor signaling.

Inhibition of farnesyltransferase activity diminishes hematopoietic stem cell ex vivo expansion ability

This study shows that inhibiting farnesyltransferase reduces the ex vivo expansion of human and mouse hematopoietic stem cells.

Developmental regulation of endothelial-to-hematopoietic transition from induced pluripotent stem cells

The paper maps single-cell dynamics of endothelial-to-hematopoietic transition from iPSCs and identifies FGF signaling modulation to improve hematopoietic output.

Multiplexed single cell transcriptomics optimizes mesodermal patterning and hemogenic endothelial output from murine embryonic stem cells

This study uses sci-Plex to analyze how Activin and BMP4 gradients affect mesoderm patterning and hemogenic endothelial cell production in mouse embryonic stem cells.

Differentiation latency, cell division symmetry, and dormancy signatures define fetal liver HSCs at single cell resolution

The paper identifies rare fetal liver HSCs with unique features like differentiation latency and dormancy signatures using single cell RNA-sequencing and a niche-mimicking culture platform.