Michael Vilkhovoy

The paper develops a dynamic constraint-based model of E. coli cell-free protein synthesis to analyze metabolic flux and protein production with and without electron transport chain inhibitors.

The paper develops a biophysical modeling approach to simulate transcription and translation in cell-free synthetic circuits, showing it captures expression dynamics for two tested circuits.

This study develops a dynamic model of E. coli cell-free protein synthesis, showing that oxidative phosphorylation, glycolysis, and amino acid biosynthesis are key for productivity.

This paper uses sequence-specific constraint-based modeling to estimate the performance of E. coli cell-free protein synthesis systems using limited parameters.