Author

Philip H. Schroeder

Broad InstituteORCID 0000-0002-9885-7787Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:GWAS / association mapping· 3 Research Focus:fine-mapping· 2 Assay:GWAS summary statistics· 2 Assay:whole-genome sequencing· 2 Assay:whole-exome sequencing· 1

Frequent Co-Authors

José C. FloreziD· 4 shared Josep Maria MercaderiD· 4 shared Alisa Knodle ManningiD· 3 shared Łukasz SzczerbińskiiD· 3 shared Miriam S. UdleriD· 3 shared Ravi MandlaiD· 3 shared Aaron J. DeutschiD· 2 shared Aaron LeongiD· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

José C. FlorezORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes

Alicia Huerta‐Chagoya, Philip H. Schroeder, Ravi Mandla, Jiang Li, Lowri Morris, Maheak Vora, Ahmed N. Alkanaq, Dorka Nagy, Łukasz Szczerbiński, Jesper Grud Skat Madsen, Sílvia Bonàs‐Guarch, Fanny Mollandin, Joanne B. Cole, Bianca Porneala, Kenneth E. Westerman, , Josep Maria Mercader

The paper conducts a large-scale rare variant GWAS meta-analysis of type 2 diabetes, identifying novel variants in monogenic diabetes genes and assessing their pathogenicity.

Nature Genetics · Oct 8, 2024Peer-reviewedGenetic & Genomic Medicine

Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People with Type 2 Diabetes Mellitus

Soo Heon Kwak, Ryan B. Hernandez-Cancela, DANIEL A. DICORPO, David E. Condon, Jordi Merino, Peitao Wu, Jennifer A. Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep Maria Mercader, Sujin Lee, Jeffrey Haessler, , James B. Meigs

This paper conducts a multi-ancestry time-to-event GWAS to identify genetic variants associated with incident cardiovascular disease in people with type 2 diabetes, finding three novel loci and confirming known CAD variants.

Diabetes Care · Apr 23, 2024Peer-reviewedGenetic & Genomic Medicine

Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity

Kirk Smith, Aaron J. Deutsch, Carolyn McGrail, Hyunkyung Kim, Sarah C Hsu, Ravi Mandla, Philip H. Schroeder, Kenneth E. Westerman, Łukasz Szczerbiński, Timothy D. Majarian, Varinderpal Kaur, Alice Williamson, Melina Claussnitzer, José C. Florez, Alisa Knodle Manning, , Miriam S. Udler

This study identifies genetic subtypes of type 2 diabetes across diverse ancestries, revealing ancestry-specific risk profiles and BMI thresholds.

medRxiv · Sep 28, 2023 · PreprintGenetic & Genomic Medicine

The power of TOPMed imputation for the discovery of Latino enriched rare variants associated with type 2 diabetes

Alicia Huerta‐Chagoya, Philip H. Schroeder, Ravi Mandla, Aaron J. Deutsch, Wanying Zhu, Lauren E. Petty, Xiaoyan Yi, Joanne B. Cole, Miriam S. Udler, Peter Dornbos, Bianca Porneala, DANIEL A. DICORPO, Ching‐Ti Liu, Josephine H. Li, Łukasz Szczerbiński, , Josep Maria Mercader

The paper demonstrates that TOPMed imputation improves the identification of rare variants associated with type 2 diabetes in Latino populations, leading to novel associations and better polygenic scores.

Diabetologia · May 6, 2023Peer-reviewedGenetic & Genomic Medicine