Xiaoyan Yi

The paper identifies ISG15 as a key factor in viral resistance in pancreatic alpha cells, showing its protective role against coxsackievirus B1 in human islet cells.

The paper shows that ER stress relief in beta cells promotes proliferation, independent of vascular recovery, by using transgene overexpression and chemical induction.

The paper demonstrates that TOPMed imputation improves the identification of rare variants associated with type 2 diabetes in Latino populations, leading to novel associations and better polygenic scores.

The paper reconstructs gene regulatory networks in human adult pancreatic cell types and identifies key transcription factors regulating cell identity.