Mauro Bombaci

Chronic cholesterol delivery via brain-permeable nanoparticles improves cognitive and motor function and reduces mutant Huntingtin aggregates in HD mice.

Combiroc refines marker signatures by selecting smaller, more discriminative subsets from scRNA-seq data, validated against independent datasets and the human protein atlas.

This study evaluates hybrid nanoparticles for delivering cholesterol to the brain in Huntington disease, showing improved targeting, controlled release, and therapeutic benefits without inflammation.