Elena F. Cattaneo

The paper identifies the proline-rich domain (PRD) of HTT exon 1 as a modifier of neuronal toxicity in Huntington's disease, showing that the human PRD exacerbates while the mouse PRD mitigates toxicity.

This study generates human cerebral organoids with a structured outer subventricular zone by activating the STAT3 pathway with LIF, mimicking in vivo oRG development and enhancing neuronal maturation.

Chronic cholesterol delivery via brain-permeable nanoparticles improves cognitive and motor function and reduces mutant Huntingtin aggregates in HD mice.

This study shows that WDR62 mutations disrupt Golgi-to-spindle pole shuttling in neural progenitors, leading to neurodevelopmental abnormalities in microcephaly.

This study compares three cortical organoid protocols to assess brain regional identity, cell type specificity, and neuronal maturation, finding that directed differentiation methods yield higher regional identity while default methods produce broader cell type diversity.

This study develops a method to generate cortico-striatal organoids from single neural rosettes to model SHANK3 deficiency in autism and intellectual disability.

This study evaluates hybrid nanoparticles for delivering cholesterol to the brain in Huntington disease, showing improved targeting, controlled release, and therapeutic benefits without inflammation.

This study shows that delivering SREBP2 to astrocytes in HD mice restores cholesterol biosynthesis and improves disease symptoms.

This study shows that striatal cholesterol infusion prevents cognitive decline and improves motor function in HD mice, with dose-dependent benefits and synaptic recovery.

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.