Genome scale modeling of the protein secretory pathway reveals novel targets for improved recombinant protein production in yeast
Feiran Li, Yu Chen, Qi Qi, Yanyan Wang, Le Yuan, Mingtao Huang, Ibrahim E. Elsemman, Amir Feizi, Eduard Johannes Kerkhoven, Jens Nielsen
The paper develops a genome-scale model of the yeast protein secretory pathway to identify targets for improving recombinant protein production, finding that the secretory pathway has more limited capacity than metabolism.
Nature Communications · May 27, 2022Peer-reviewedSystems Biology